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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13269Generated: October 25, 2026

3-Bromobenzonitrile → 3-(6-(1-Acetyl-pyrrolidin-2-yl)-2-pyridin-2-yl-1H-benzimidazol-5-yloxy)-benzonitrile

https://huagongshe.com/reaction/13269

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromobenzonitrileHCID 23381—
Reactant1-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanoneHCID 23145277—
Product3-(6-(1-Acetyl-pyrrolidin-2-yl)-2-pyridin-2-yl-1H-benzimidazol-5-yloxy)-benzonitrileHCID 23145121—

Reaction Steps

The entitled compound was obtained as an oily substance in the same method as in Example 121 (step 11), (step 12) or in accordance with the method or by combining it with an ordinary method but using 1-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone obtained in Example 121 (step 10) and 3-cyanobromobenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-34f455e98852447aadb9e7dea234af3f
Source noteuspto-grants-2010_06