反应详情

The product of step G prepared above (152 mg) was dissolved in anhydrous dichloromethane (3.0 mL). Trimethylsilyl bromide (0.5 mL) was added at 0° C. The mixture was stirred during 1 h at this temperature and overnight at room temperature. The solvent was evaporated and 0.2 mL water was added to the residue. 3 mL EtOH was added mixed and evaporated. This step was repeated three times and the residue dried in vacuo. Yields 98 mg 70% of the title derivatives of this first example.

1. customThe solvent was evaporated
2. addition0.2 mL water was added to the residue
3. addition3 mL EtOH was added
4. additionmixed
5. customevaporated
6. customthe residue dried in vacuo
7. customYields 98 mg 70% of the title derivatives of this first example