HCID 11636114, compound → HCID 11534890, compound

HRID 132698Notes

Reaction equation

COC(=O)N[C@H](C(=O)[NH:18][CH2:19][CH2:20][CH2:21][CH2:22][C@H:23]([N:30]([S:35]([C:38]1[CH:43]=[CH:42][C:41]([NH2:44])=[CH:40][CH:39]=1)(=[O:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33])[CH2:24][O:25][P:26]([OH:29])([OH:28])=[O:27])CC1C=CC2C(=CC=CC=2)C=1.[C:47]([NH:50][C@@H:51]([CH:55]([C:62]1[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=1)[C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1)[C:52](O)=[O:53])(=[O:49])[CH3:48]>>[C:47]([NH:50][C@@H:51]([CH:55]([C:62]1[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=1)[C:56]1[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=1)[C:52]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][C@H:23]([N:30]([S:35]([C:38]1[CH:43]=[CH:42][C:41]([NH2:44])=[CH:40][CH:39]=1)(=[O:37])=[O:36])[CH2:31][CH:32]([CH3:33])[CH3:34])[CH2:24][O:25][P:26](=[O:27])([OH:28])[OH:29])=[O:53])(=[O:49])[CH3:48]

Participants

Reactant 2

HCID 11636114HCID 11636114, compound

HCID 15940258HCID 15940258, compound

Product 1

HCID 11534890HCID 11534890, compoundYield 30%

Procedure

This compound was made as for the preparation of the product of example 3 (step D) with 100 mg of (2S)-2-acetylamino-3,3-diphenyl-propionic acid (this example step A). The final product was obtained in 30% yield (30 mg).

Sources & evidence

ORD record: ord-559059181a284a81aaffe22342c09086
Source dataset: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07388008B2

Reaction notes

Loading…