反应详情

To the reactor were added 1,2-butylene-glycol (2.5 g), benzoyl chloride (7.8 g), pyridine (8.8 g) and tetrahydrofuran (70 ml). The reactants was mixed and heated refluxing for 4 hours, then cooled to room temperature. Water was added to the reaction system until the inorganic phase was transparent. Organic phase was separated. Inorganic phase was extracted with ethyl ether. The combined organic phase was washed with water, dried over anhydrous sodium sulfate. After concentrated, 3.95 g product was separated. 1H-NMR: δ (ppm)1.0-1.1 (3H), 1.7-1.9(2H), 4.4-4.6(2H), 5.4-5.5(1H) and 7.4-8.2(10H).

1. additionThe reactants was mixed
2. temperatureheated
3. temperaturerefluxing for 4 hours
4. customOrganic phase was separated
5. extractionInorganic phase was extracted with ethyl ether
6. washThe combined organic phase was washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationAfter concentrated
9. custom3.95 g product was separated