反应详情

0.030 ml of hydrazine monohydrate and 20 mg of developed Raney nickel catalyst were added to an ethanol (1 ml) solution of 72 mg of 1-(2-(6-(3,4-dinitro-phenoxy)-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone, and the reaction liquid was stirred at room temperature for 2 hours. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure. The resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1) to obtain the entitled compound as a brown oily substance.

1. customthe reaction liquid
2. customThe catalyst was removed through filtration through Celite
3. customthe solvent was evaporated away under reduced pressure
4. customThe resulting residue was purified
5. customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=9/1)
6. customto obtain the entitled compound as a brown oily substance