HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1327255Generated: October 31, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1327255
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Catalyst | (2,2'-Bipyridine)-5,5'-dicarboxylic acid | HCID 192744 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 8.63% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 0% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-5c4d254eeb40494baa715d0a25659713 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
