反应详情

To 3 g LiAlH4 was added 100 ml anhydrous ethyl ether. While cooling with ice-bath and stirring intensely, 0.05 mol diethyl 2,2′-biphenyldicarboxylate was slowly added dropwise. The reaction mixture was heated refluxing for 5 hours, then cooled. Excess LiAlH4 was decomposed with water. The mixture was filtered, and the filtrate was extracted with ethyl ether. The extract was dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2,2′-biphenyldimethanol as a white solid, the yield was 75%, and m.p. was 98-103° C. IR spectrum had a strong absorption peak at 3400 cm−1, and had no absorption peak at about 1700 cm−1. This demonstrated that the reduction reaction was carried out completely.

1. temperatureWhile cooling with ice-bath
2. temperatureThe reaction mixture was heated
3. temperaturerefluxing for 5 hours
4. temperaturecooled
5. filtrationThe mixture was filtered
6. extractionthe filtrate was extracted with ethyl ether
7. dry with materialThe extract was dried over anhydrous sodium sulfate
8. customThe solvent was removed