Dichloromethane → HCID 69199038, compound

Participants

Reaction Steps

12.4 grams of 2-benzyl-2-ethoxycarbonyl-cyclopentanol obtained from Example 14 were diluted using 60 ml of methylene chloride. At room temperature and with magnetic stirring, 6.108 ml of pyridine was slowly added, then 8.876 ml of benzoyl chloride was dropwise added Upon the completion of the addition, the reaction was continued for 12 hours. Then solvent was removed, and the residue was extracted using ethyl acetate and water. Organic layer was washed, in turn, using 10% hydrochloric acid aqueous solution to pH of about 2, using saline solution to neutrality, and then using 10% aqueous solution of sodium carbonate for three times. The organic layer was dried, and removing solvent gave 19.71 g of yellow liquid. MS: m/e 353(M++1), 352(M+), 351(M+−1), 279(M+—CO2CH2CH3), 261(M+—CH2C6H5), 247(M+—C6H5CO), 231(M+—C6H5CO2), 201, 184, 156, 139, 105 (base), 91, 77.

Provenance & Evidence