Pyridine → HCID 69199446, compound

HRID 132777Notes

Reaction equation

HRID 132777 reaction equation
[CH2:1]([C:5]1([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:9][CH2:8][CH2:7][CH:6]1[OH:10])[CH2:2][CH2:3][CH3:4].N1C=CC=CC=1.[CH3:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1>C(Cl)Cl>[CH2:1]([C:5]1([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:9][CH2:8][CH2:7][CH:6]1[O:10][C:27](=[O:28])[C:26]1[CH:30]=[CH:31][C:23]([CH3:22])=[CH:24][CH:25]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 1049PyridineHCID 134054-Methylbenzoyl ChlorideHCID 69199000HCID 69199000, compound

Product 1

HCID 69199446HCID 69199446, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6.42 grams of ethyl 1-n-butyl-2-hydroxy-cyclopentane carboxylate obtained in Example 16 were diluted with 60 ml of methylene chloride. At room temperature and with magnetic stirring, 3.66 ml of pyridine was slowly added, then 6.12 ml of 4-methyl-benzoyl chloride was dropwise added. Then the procedure as described in Example 23 was followed, to give 11.77 g of brown liquid. MS: m/e 332(M+′), 287(M+—OCH2CH3), 213(M+—CH3C6H4CO), 197(M+—CH3C6H4CO2), 119 (base), 91.

Sources & evidence

ORD record
ord-37a7da5258c44d7e831b9df1bdef1232
Source dataset
uspto-grants-2008_06
Patent number
US07388103B2

Reaction notes

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