HCID 21973129, compound → 1-(2-(5-(4-(methylsulfonyl)phenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone

Participants

Role	Name	HCID	Charge
Reactant	HCID 21973129	HCID 21973129	—
Reactant	5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole	HCID 23145175	—
Product	1-(2-(5-(4-(methylsulfonyl)phenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone	HCID 11179025	—

Reaction Steps

230 mg of 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) was optically resolved, using an optical resolution column (CHIRALPAK AD 2 cmφ×25 cmL (by Daicel Chemical), mobile phase: hexane/2-propanol/diethylamine=20/80/0.1, flow rate: 10 ml/min), into an enantiomer A (retention time: 19.0 min) and an enantiomer B (retention time: 32.2 min) each as a yellow oily substance.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07728025B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-c4b102d9de8e4ac68969a01a810b2e1e
Source note	uspto-grants-2010_06