4-Amino-3-bromobenzene-1-sulfonamide → 2-[3-Bromo-4-(3-cyano-5-difluoromethyl-phenoxy)-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide

HRID 132794Notes

Reaction equation

HRID 132794 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([S:30](=[O:33])(=[O:32])[NH2:31])=[CH:26][C:25]=2Br)=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[C:13]([CH:15]([F:17])[F:16])[CH:12]=[C:11]([C:18]#[N:19])[CH:10]=1.N[C:36]1C=CC(S(N)(=O)=O)=CC=1Br>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([NH:23][C:24]2[CH:29]=[CH:28][C:27]([S:30](=[O:33])(=[O:32])[NH2:31])=[CH:26][C:25]=2[CH3:36])=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[C:13]([CH:15]([F:16])[F:17])[CH:12]=[C:11]([C:18]#[N:19])[CH:10]=1

Participants

3

Reactant 2

HCID 35265234-Amino-3-bromobenzene-1-sulfonamideHCID 497681052-[3-Bromo-4-(3-cyano-5-difluoromethyl-phenoxy)-phenyl]-N-(2-bromo-4-sulfamoyl-phenyl)-acetamide

Product 1

HCID 162238622-[3-Bromo-4-(3-cyano-5-difluoromethyl-phenoxy)-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide

Procedure

2-[3-Bromo-4-(3-cyano-5-difluoromethyl-phenoxy)-phenyl]-N-(2-bromo-4-sulfamoyl-phenyl)-acetamide I-64) was prepared analogously except in step 4, 4-amino-3-bromo-benzenesulfonamide was used in place of 4-amino-3-methyl-benzenesulfonamide.

Sources & evidence

ORD record
ord-4215138b025e4ab3b5663e9aaa498c3a
Source dataset
uspto-grants-2008_06
Patent number
US07388111B2

Reaction notes

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