HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butyl (1S)-1-(3,5-difluorobenzyl)-2-oxobut-3-enylcarbamate → Tert-Butyl (1S)-1-(3,5-difluorobenzyl)-2-hydroxybut-3-enylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butyl (1S)-1-(3,5-difluorobenzyl)-2-oxobut-3-enylcarbamate | HCID 86591229 | — |
| Reactant | Sodium borohydride cerium chloride | HCID 131723797 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-Butyl (1S)-1-(3,5-difluorobenzyl)-2-hydroxybut-3-enylcarbamate | HCID 86591230 | — |
Reaction Steps
Ketone (2) was reduced with sodium borohydride/cerium chloride (Luche conditions) in methanol at 0° C. to provide the allylic alcohol 3 as a mixture of alcohol epimers (white solid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388118B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-9751ade2cea64cabb0c400d8d50b2ecf |
| Source note | uspto-grants-2008_06 |