HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → tert-Butyl ((S)-2-(3,5-difluorophenyl)-1-((R)-oxiran-2-yl)ethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 86591234 | HCID 86591234 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | tert-Butyl ((S)-2-(3,5-difluorophenyl)-1-((R)-oxiran-2-yl)ethyl)carbamate | HCID 11415322 | — |
Reaction Steps
Mesylate 30 was dissolved in methanol/water at 0° and a solution of sodium hydroxide in water was added. After all of the starting material was consumed, the reaction was extracted and the residue purified using silica gel chromatography to obtain epoxide 31 as a white solid, m.p.=99°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388118B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-3d3853ff46f0442b9c10b4a6c04efd6c |
| Source note | uspto-grants-2008_06 |