Morpholine → [5-(3-Chloro-propoxy)-1H-indol-2-yl]-morpholin-4-yl-methanone

Participants

Role	Name	HCID	Charge
Reactant	Morpholine	HCID 8083	—
Reactant	5-(3-Chloro-propoxy)-1H-indole-2-carboxylic acid	HCID 67526619	—
Reactant	[5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 67527268	—
Product	[5-(3-Chloro-propoxy)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 67527317	—

Reaction Steps

In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-(3-chloro-propoxy)-1H-indole-2-carboxylic acid (Example 4, step 2) and morpholine. The desired product was obtained as white solid in 84% yield. MS (m/e): 324.0 (MH+, 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07388095B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-2873337c614f432cb9385c514ca647bd
Source note	uspto-grants-2008_06