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Morpholine → (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 5-Hydroxyindole-2-carboxylic acid | HCID 88958 | — |
| 反応物 | [5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone | HCID 67527268 | — |
| 生成物 | (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone | HCID 44185244 | — |
反応手順
In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid (purchased at Fluka, Ref 55355) and morpholine. The desired product was obtained in 86% yield as white solid. MS (m/e): 493.1 (2M+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388095B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-3d1545c0174344af888da1f2167d0abb |
| 出典メモ | uspto-grants-2008_06 |