HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Difluoropiperidine hydrochloride → (4,4-Difluoro-piperidin-1-yl)-[5-hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Difluoropiperidine hydrochloride | HCID 2758351 | — |
| Reactant | [5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone | HCID 67527268 | — |
| Product | (4,4-Difluoro-piperidin-1-yl)-[5-hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-methanone | HCID 67526963 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indole-2-carboxylic acid (Intermediate 1, step 3) and 4,4-difluoropiperidine hydrochloride. The title product was obtained in 80% as white solid. MS (m/e): 361 (M−H−, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07388095B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-13623c73b18a42c18a5fc3b93dd2af89 |
| Source note | uspto-grants-2008_06 |