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(2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine → Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-[(2,4,5-trifluorophenyl)methyl]-, (2S,5R)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine | HCID 736065 | — |
| 反応物 | 2,4,5-Trifluorobenzyl Bromide | HCID 2777057 | — |
| 生成物 | Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-5-[(2,4,5-trifluorophenyl)methyl]-, (2S,5R)- | HCID 11290377 | 62.7% |
反応手順
The title compound (3.81 g) was prepared from 3.42 g (18.5 mmol) of (2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine and 5 g (22.3 mmol) of 2,4,5-trifluorobenzyl bromide using the procedure described for Intermediate 2, Step A.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388019B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-540da271cfc542548cd906ed04797527 |
| 出典メモ | uspto-grants-2008_06 |