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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 132862Generated: October 26, 2026

Trifluoroacetic acid → 2-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine

https://huagongshe.com/reaction/132862

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant6-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 69223721—
SolventDichloromethaneHCID 6344—
Product2-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidineHCID 53471483—

Reaction Steps

Reaction of the product from Step A above with trifluoroacetic acid in dichloromethane according to the procedure outlined for Intermediate 28, Step C afforded the title compound as a white powder. LC/MS 204.0 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07388019B2
Source datasetuspto-grants-2008_06
ORD IDord-cc45c23990ba456899627ba7fa8afba1
Source noteuspto-grants-2008_06