Hydrochloric Acid → 7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-N-(tert-butyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxamide, hydrochloride

Participants

Reaction Steps

A solution of the product (25 mg) from Step A above, 0.5 mL of methanol and 2.5 mL of 4.0M hydrogen chloride in 1,4-dioxane was kept at room temperature for 18 h. The volatiles were removed under a stream of nitrogen, and the residue was triturated with ether. The resultant precipitate was collected and dried in vacuo to afford the title compound as a white powder. LC/MS: 499.1 (M+1).

Provenance & Evidence