Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-Chloro-3-methylbenzoyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-Chloro-3-methylbenzoic acid | HCID 282989 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Chloro-3-methylbenzoyl chloride | HCID 13058375 | — |
반응 단계
To a suspension of 52.55 g (0.31 mol) of 4-chloro-3-methyl-benzoic acid in CH2Cl2 (1.2 L) with DMF (1 mL) at 0° C. under N2 with an outlet sparging through 2.5 N sodium hydroxide was added 29.56 mL (0.339 mol) of oxalyl chloride. The mixture was allowed to warm to room temperature over a 3 h period. The reaction mixture was concentrated and taken forward crude.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388011B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-04efb45b1d8c4d0fbf9c78969fce8285 |
| 출처 메모 | uspto-grants-2008_06 |