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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1329816Generated: November 3, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1329816

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentHCID 14574551HCID 14574551—
CatalystCuprous chlorideHCID 62652—
CatalystSTK051972HCID 330826—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-f5bf2f94f972455c8829c70c54db6454
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions