6,7-Dihydro-2H-benzo[6,7]cyclohepta[cd]indazol-5-ylmethanol → 6,7-Dihydro-2H-benzo[6,7]cyclohepta[cd]indazole-8-carboxaldehyde

HRID 132992Notes

Reaction equation

HRID 132992 reaction equation
[N:1]1[NH:2][C:3]2[CH:4]=[CH:5][C:6]([CH2:18][OH:19])=[C:7]3[CH2:13][CH2:12][C:11]4[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=4[C:9]=1[C:8]=23>[O-2].[O-2].[Mn+4]>[N:1]1[NH:2][C:17]2[CH:16]=[CH:15][CH:14]=[C:11]3[CH2:12][CH2:13][C:7]4=[C:6]([CH:18]=[O:19])[CH:5]=[CH:4][CH:3]=[C:8]4[C:9]=1[C:10]=23

Participants

3

Reactant 1

HCID 101252656,7-Dihydro-2H-benzo[6,7]cyclohepta[cd]indazol-5-ylmethanol

Product 1

HCID 102145986,7-Dihydro-2H-benzo[6,7]cyclohepta[cd]indazole-8-carboxaldehydeYield 100.8%

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

210 mg of 6,7-dihydro-2H-benzo[6,7]cyclohepta[cd]indazol-8-ylmethanol obtained in Example 1-h was treated by the procedure of Example 1-f using 500 mg of manganese dioxide, to give 210 mg of the title compound as a colorless powder.

Sources & evidence

ORD record
ord-d68e17e9ba6946269005744d39c9b759
Source dataset
uspto-grants-2008_06
Patent number
US07390797B2

Reaction notes

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