Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1329971Generated: October 30, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1329971

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCID 21226062HCID 21226062—
CatalystCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Catalyst1,3-Bis(2,6-di(pentan-3-yl)phenyl)-1H-iMidazol-3-iuM chlorideHCID 92132781—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-0b51ee3616f1497d8508b3767dafd2fa
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions