反应详情

Phenyl glyoxal (1.0 g, 7.46 mmol) and cyanoacetohydrazide (740 mg, 7.46 mmol) were heated to reflux in 10 mL ethanol for 16 hours. After cooling, the solvent was evaporated and the crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane). The still impure product was further recrystallized from methanol affording 70 mg pure product.

1. temperatureAfter cooling
2. customthe solvent was evaporated
3. customthe crude brown mixture was purified by silica chromatography (1:9 methanol/dichloromethane)
4. customThe still impure product was further recrystallized from methanol affording 70 mg pure product