Phosphorus oxychloride → HCID 17979843, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 8.0 g of 6-methoxy-3-nitroquinoline-1-oxide (compound D3) in 80 ml of phosphorus oxychloride is stirred at 100° C. for 30 min. After cooling to room temperature, the reaction mixture is added to 500 ml of ice water, diluted with 250 ml of dichloromethane and extracted three times each with 250 ml of a halfsaturated aqueous potassium carbonate solution. The organic layer is dried using magnesium sulfate, filtered and evaporated in vacuo. The residue is recrystallized from diethylether to give 5.6 g of the title compound as violet solid.

Provenance & Evidence