2-(4-tert-butyl-phenyl)-8-nitro-2H-phthalazin-1-one → 8-amino-2-(4-tert-butyl-phenyl)-2H-phthalazin-1-one

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Reaction Steps

A solution of the nitro compound (Step D) and EtOAc (10 mL) was hydrogenated over 10% Pd/C (20 mg) at RT and at atmospheric pressure. After 4 h, the mixture was filtered through Celite® and concentrated in vacuo to afford the desired compound as an orange oil. MS m/e 294 (M+H)+. Calc'd for C18H19N3O: 293.15.

Provenance & Evidence