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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13312Generated: October 26, 2026

1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2,3-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

https://huagongshe.com/reaction/13312

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-methyl-1H-pyrazole-3-carboxylic acidHCID 573176—
Reactant5-(2,3-Difluoro-phenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazoleHCID 23145563—
Product5-(2,3-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazoleHCID 135421358—

Reaction Steps

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2,3-difluoro-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 226 and 1-methyl-1H-pyrazole-3-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-1fd26766acf74d00b74e3d37837a1bc3
Source noteuspto-grants-2010_06