Methyl pyrazine-2-carboximidate → HCID 23145709, compound

HRID 13315Notes

Reaction equation

HRID 13315 reaction equation
[F:1][C:2]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=C[CH:15]=[CH:14][N:13]=3)=[N:11][C:7]=2[CH:6]=1.COC(C1C=NC=CN=1)=[NH:40]>>[F:1][C:2]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:12]3[CH:17]=[N:40][CH:15]=[CH:14][N:13]=3)=[N:11][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 470894Methyl pyrazine-2-carboximidateHCID 11295135HCID 11295135, compound

Product 1

HCID 23145709HCID 23145709, compound

Procedure

The entitled compound was obtained as a white solid in the same method as in Example 205 or in accordance with the method or by combining it with an ordinary method but using 4-(2,5-difluoro-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 232 and methylpyrazin-2-imidate.

Workup

  1. customThe entitled compound was obtained as a white solid in the same method as in Example 205 or in accordance with the method

Sources & evidence

ORD record
ord-97568e56618247fe8e4086f3750a3f51
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Reaction notes

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