Ethanol → Ethyl 4-hydrazinylbenzoate

HRID 133175Notes

Reaction equation

HRID 133175 reaction equation
[NH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)[NH2:2].[CH2:12](O)[CH3:13]>OS(O)(=O)=O>[NH:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][CH2:12][CH3:13])=[O:8])=[CH:10][CH:11]=1)[NH2:2]

Participants

4

Reactant 2

HCID 702EthanolHCID 120894-Hydrazinobenzoic acid

Product 1

HCID 792992Ethyl 4-hydrazinylbenzoate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

5.0 g of 4-hydrazinobenzoic acid are dissolved in 70 ml of ethanol and 3 ml of concentrated H2SO4. The mixture is heated at reflux for five hours, the ethanol is evaporated, the residue is then taken up in a saturated K2CO3 solution and then extraction is carried out with AcOEt. 5.9 g of the expected compound are obtained in the form of a powder.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for five hours
  3. customthe ethanol is evaporated
  4. extractionextraction

Sources & evidence

ORD record
ord-77f648d3b85f4ef89e0d09bda732dd17
Source dataset
uspto-grants-2008_06
Patent number
US07390818B2

Reaction notes

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