Ethanol → Ethyl 2-(3,5-difluorophenyl)acetate

HRID 133179Notes

Reaction equation

HRID 133179 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:13](O)[CH3:14]>OS(O)(=O)=O>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 1454243,5-Difluorophenylacetic acid

Product 1

HCID 11481060Ethyl 2-(3,5-difluorophenyl)acetate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

5 g of 3,5-difluorophenylacetic acid are dissolved in 50 ml of ethanol and 3 ml of concentrated H2SO4, and the mixture is heated at reflux for two hours. The mixture is evaporated to dryness, neutralization is then carried out with a saturated K2CO3 solution, extraction is then carried out with AcOEt and the organic phase is evaporated to produce 5.0 g of the expected compound in the form of a colourless liquid.

Workup

  1. temperatureat reflux for two hours
  2. customThe mixture is evaporated to dryness, neutralization
  3. extractionis then carried out with a saturated K2CO3 solution, extraction
  4. customthe organic phase is evaporated

Sources & evidence

ORD record
ord-89ebcdc441824ec9b27c3df3b632d587
Source dataset
uspto-grants-2008_06
Patent number
US07390818B2

Reaction notes

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