(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-delta-valerolactam

HRID 133219Notes

Reaction equation

HRID 133219 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]1[CH2:25][CH2:24][NH:23][C:21](=[O:22])[CH2:20]1>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][CH:19]2[CH2:25][CH2:24][NH:23][C:21](=[O:22])[CH2:20]2)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 199802604-Aminopiperidin-2-one

Product 1

HCID 99677223-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-delta-valerolactam

Procedure

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-δ-valerolactam (prepared by the procedure of D. W. Adamson, J. Chem. Soc. 1943, 39), the title compound was prepared.

Workup

  1. customprepared by the procedure of D

Sources & evidence

ORD record
ord-88981694d9b84b30ab7564181414f3c9
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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