(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-3-one

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid	HCID 12135350	—
Reactant	4-Amino-2-phenethyl-1,2,3,4-tetrahydroisoquinoline-3-one	HCID 22312129	—
Product	4-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-3-one	HCID 10117314	—

Reaction Steps

Following General Procedure D above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-2-phenethyl-1,2,3,4-tetrahydroisoquinoline-3-one (General Procedure 5-D), the title compound was prepared as a solid having a melting point of 75-76° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07390801B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-f5e491fa6b604540bb99bf9aa6a6a9c7
Source note	uspto-grants-2008_06