(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 10181033, compound

HRID 133238Notes

Reaction equation

HRID 133238 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][CH:19]1[CH2:25][CH:24]([CH3:26])[C:23]2[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=2[N:21]([CH3:31])[C:20]1=[O:32]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][CH:19]2[CH2:25][CH:24]([CH3:26])[C:23]3[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=3[N:21]([CH3:31])[C:20]2=[O:32])=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 22312414HCID 22312414, compound

Product 1

HCID 10181033HCID 10181033, compound

Procedure

Following General Procedure C above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (prepared from 4-methyltetralone (Aldrich) using General Procedure 6-A), the title compound was prepared as a solid having a melting point of 115-119° C. Purification was by flash chromatography using 5% methanol/dichloromethane as the eluant.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-9a8052b6688a4372b82d017b3d1e104c
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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