Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- → HCID 131726941, compound

HRID 133253Notes

Reaction equation

HRID 133253 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:13])[CH:12]=1)[C@H:5]([OH:9])[C:6]([OH:8])=O.Cl.[NH2:15][C@H:16]([C:18]([NH:20][N:21]1[C:27](=[O:28])[CH:26]([CH2:29][CH:30]2[CH2:32][CH2:31]2)[C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[C:23]2[CH:37]=[CH:38][CH:39]=[CH:40][C:22]1=2)=[O:19])[CH3:17]>>[F:13][C:11]1[CH:10]=[C:4]([CH:3]=[C:2]([F:1])[CH:12]=1)[C@H:5]([OH:9])[C:6]([NH:15][C@H:16]([C:18]([NH:20][N:21]1[C:27](=[O:28])[CH:26]([CH2:29][CH:30]2[CH2:32][CH2:31]2)[C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[C:23]2[CH:37]=[CH:38][CH:39]=[CH:40][C:22]1=2)=[O:19])[CH3:17])=[O:8]

Participants

3

Reactant 2

HCID 6951479Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-HCID 22984572HCID 22984572, compound

Product 1

HCID 131726941HCID 131726941, compound

Procedure

Following General Procedure D and using (S)-3,5-difluoromandelic acid (Example L) and 5-(L-alaninyl)-amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride (Example 7-R), the title compound was prepared. The product was purified by chromatography (silica, 2.5% MeOH/CHCl3).

Workup

  1. customThe product was purified by chromatography (silica, 2.5% MeOH/CHCl3)

Sources & evidence

ORD record
ord-544756719a97439195b9e1f1f1bae925
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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