Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromomethylcyclopropane → 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromomethylcyclopropane | HCID 81503 | — |
| 반응물 | 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione | HCID 283534 | — |
| 생성물 | 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 577192 | — |
반응 단계
2,4-Dioxo-1,5-bis-cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 8-M using the product from Example 8-P, Step A, and (bromomethyl)cyclopropane (Lancaster). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to straight EtOAc), then recrystallization from EtOAc/hexanes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07390801B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-03a25caae3a44a6f8640ed336cd0ef0e |
| 출처 메모 | uspto-grants-2008_06 |