HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3,5-Difluorophenyl)-2-fluoroacetic acid → 3-[N'-(3,5-Difluorophenyl-alpha-fluoroacetyl)-L-alaninyl]amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3,5-Difluorophenyl)-2-fluoroacetic acid | HCID 22312719 | — |
| Reactant | 3-(L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one | HCID 23552762 | — |
| Product | 3-[N'-(3,5-Difluorophenyl-alpha-fluoroacetyl)-L-alaninyl]amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4benzodiazepin-2-one | HCID 22984125 | — |
Reaction Steps
Following General Procedure D above using 3,5-difluorophenyl-α-fluoroacetic acid (Example S) and 3-(L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one (Example 8-Y), the title compound was prepared as a solid. The product was purified by LC 2000 chromatography, eluting with hexanes/ethyl acetate (35:65).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390801B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-97e4db836f1a4285be9f8a1630b92fc7 |
| Source note | uspto-grants-2008_06 |