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HRID133289

反应详情

EQUATION

反应方程式

HRID 133289 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)CC1CC1
HCID138440

Cyclopropaneacetic acid

C5H8O2

结构：CC(C)CN1C(=O)C(NC(=O)[C@H](C)N)C(=O)N(CC(C)C)c2ccccc21.Cl
HCID23552766

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CN1C(=O)C(N)(C(=O)[C@H](C)NC(=O)CC2CC2)C(=O)N(CC(C)C)c2ccccc21
HCID86584977

未命名化合物

PROCEDURE

实验过程

Following General Procedure I above using cyclopropylacetic acid (Lancaster) and 3-(L-alaninyl)amino-2,4-dioxo-1,5-bis-(2-methylpropyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine hydrochloride (Example 8-S), the title compound was prepared as a white solid (melting point=190-191° C.). Purification was by flash chromatography eluting with CH2Cl2/EtOAc (1:1 gradient to 3:4) and a second flash chromatography eluting with EtOAc/Toluene (7:3). Rf=0.28 (EtOAc/Toluene, 7:3).

WORKUP

后处理

  1. customPurification
  2. washeluting with CH2Cl2/EtOAc (1:1 gradient to 3:4)
  3. washa second flash chromatography eluting with EtOAc/Toluene (7:3)