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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13330Generated: October 25, 2026

5-Bromopyridine-2-carbonitrile → 5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole

https://huagongshe.com/reaction/13330

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromopyridine-2-carbonitrileHCID 817154—
Reactant5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazoleHCID 135697984—
Product5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazoleHCID 23145142—

Reaction Steps

The entitled compound was obtained as a yellow solid in the same method as in Example 251 (step 2) or in accordance with the method or by combining it with an ordinary method but using 5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 251 (step 1) and 5-bromo-2-cyanopyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-badeeb24b3bb487ca7ac18271e18a665
Source noteuspto-grants-2010_06