HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromopyridine-2-carbonitrile → 5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromopyridine-2-carbonitrile | HCID 817154 | — |
| Reactant | 5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole | HCID 135697984 | — |
| Product | 5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole | HCID 23145142 | — |
Reaction Steps
The entitled compound was obtained as a yellow solid in the same method as in Example 251 (step 2) or in accordance with the method or by combining it with an ordinary method but using 5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 251 (step 1) and 5-bromo-2-cyanopyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728025B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-badeeb24b3bb487ca7ac18271e18a665 |
| Source note | uspto-grants-2010_06 |