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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 133317Generated: October 27, 2026

3,4-Dichloroaniline → N-(3,4-dichlorophenyl)alanine Methyl Ester

https://huagongshe.com/reaction/133317

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DichloroanilineHCID 7257—
ReactantMethyl pyruvateHCID 11748—
ProductN-(3,4-dichlorophenyl)alanine Methyl EsterHCID 54289412—

Reaction Steps

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and methyl pyruvate (Aldrich), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.55 in 25% EtOAc/hexanes) and purification was by flash chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07390801B2
Source datasetuspto-grants-2008_06
ORD IDord-2c1e753c395146de903ffd355d886fcb
Source noteuspto-grants-2008_06