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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 13336Generated: October 26, 2026

3-Pyridinol, 2-(difluoromethoxy)- → 5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole

https://huagongshe.com/reaction/13336

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Pyridinol, 2-(difluoromethoxy)-HCID 23145109—
Reactant5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 23145140—
Product5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 23145275—

Reaction Steps

The entitled compound was obtained as a pale yellow solid in the same method as in Example 14 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14 and 2-difluoromethoxy-pyridin-3-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07728025B2
Source datasetuspto-grants-2010_06
ORD IDord-12697cafd3ab4595aca6a3592bc87235
Source noteuspto-grants-2010_06