3,4-Dichlorophenylacetic acid → 2-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 133361Notes

Reaction equation

HRID 133361 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 543898612-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 3,4-dichlorophenylacetic acid (Aldrich) and isobutyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Sources & evidence

ORD record
ord-7c3f8542f4004f66929352803552d72c
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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