2-Thiopheneacetic acid → 2-[(2-Thienyl)acetamido]butyric acid isobutyl ester

HRID 133376Notes

Reaction equation

HRID 133376 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:9])=O.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 159702-Thiopheneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 544436822-[(2-Thienyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 2-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by dc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by dc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-8ed8181bf0e04a71ae3a25e77b78e5f2
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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