2-(1-Benzofuran-2-yl)acetic acid → N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

HRID 133382Notes

Reaction equation

HRID 133382 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][C:11]([OH:13])=O.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:11](=[O:13])[CH2:10][C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1)[CH:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 111058882-(1-Benzofuran-2-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481779N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure BI above, and using benzofuran-2-ylacetic acid (Maybridge) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-7af4a07c51064a0599b0c456b7ab55f0
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

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