2-methylpropyl (2S)-2-aminopropanoate → N-[(3-phenyl-1,2,4thiadiazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 133384Notes

Reaction equation

HRID 133384 reaction equation
[C:1]1([C:7]2[N:11]=[C:10]([CH2:12][C:13]([OH:15])=O)[S:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH2:23])[CH:17]([CH3:19])[CH3:18]>>[CH2:16]([O:20][C:21](=[O:25])[C@H:22]([CH3:24])[NH:23][C:13](=[O:15])[CH2:12][C:10]1[S:9][N:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:11]=1)[CH:17]([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 224921842-(3-Phenyl-1,2,4-thiadiazol-5-yl)acetic acid

Product 1

HCID 22894976N-[(3-phenyl-1,2,4thiadiazol-5yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure BI above, and using (3-phenyl-1,2,4-thiadiazol-5-yl)acetic acid (CAS#90771-06-5) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-3e0de9ccea424d40b2d2f75e29bb5135
Source dataset
uspto-grants-2008_06
Patent number
US07390801B2

Reaction notes

Loading…