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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 133386Generated: October 25, 2026

3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

https://huagongshe.com/reaction/133386

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant2-methylpropyl (2S)-2-aminopropanoateHCID 13743556—
ProductN-[(3,5-difluorophenyl)acetyl]alanine iso-butyl esterHCID 22894975—

Reaction Steps

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07390801B2
Source datasetuspto-grants-2008_06
ORD IDord-f737f9ccb97f43ba870e1481f14c8140
Source noteuspto-grants-2008_06