Potassium Carbonate → 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol	HCID 2734624	—
반응물	2-(Bromomethyl)-1-benzofuran	HCID 12326316	—
용매	Acetonitrile	HCID 6342	—
생성물	2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran	HCID 67109971	63%

반응 조건

온도	70 °C

반응 단계

To 2-Bromomethyl-benzofuran (1.5 g, 7.1 mmol, 1 eq.), 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol (1.56 g, 7.1 mmol, 1 eq.), potassium carbonate (1.96 g, 14.2 mmol, 2 eq.) was dissolved in acetonitrile (50 mL) under argon and heated at 70° C. for 16 hours. After work-up and flash column chromatography, 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran is obtained. Yield: 63%. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.3 (s, 12 H) 5.3 (s, 2 H) 7.1 (m, 3 H) 7.3 (m, 1 H) 7.3 (m, 1 H) 7.6 (m, 4 H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07390833B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-9ead8a52ba40434b88e6de9e5256fbc2
출처 메모	uspto-grants-2008_06