HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-(chloromethyl)benzene → 3-(5-Bromo-3-pyridyl)-4-(4-chlorophenyl)-2-butanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | 1-(3-Bromophenyl)propan-2-one | HCID 2734093 | — |
| Reactant | 1-(5-Bromopyridin-3-yl)propan-2-one | HCID 17750147 | — |
| Product | 3-(5-Bromo-3-pyridyl)-4-(4-chlorophenyl)-2-butanol | HCID 22270445 | — |
Reaction Steps
The title compound was prepared following the procedures described in Reference Example 40, Step B-C, substituting 2-bromomethyl-5-chloropyridine with 4-chlorobenzyl chloride and 3-bromophenylacetone with 5-bromo-3-pyridylacetone (Step A). 1H NMR (500 MHz, CD3OD): δ 8.43 (d, 1H), 8.24 (d, 1H), 7.98 (dd, 1H), 7.17 (d, 2H), 7.07 (d, 2H), 4.04 (m, 1H), 3.16 (dd, 1H), 3.0-2.9 (m, 2H), 1.04 (d, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07390835B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-ef763848021b4c3bade3a5ff56003b45 |
| Source note | uspto-grants-2008_06 |