Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1334708Generated: October 28, 2026

3-Bromopyridine → 3-(4-Phenyl-1-piperidinyl)pyridine

https://huagongshe.com/reaction/1334708

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-BromopyridineHCID 12286—
Reactant4-PhenylpiperidineHCID 69873—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
CatalystBenzenamine, 4-(dicyclohexylphosphino)-N,N-dimethyl-HCID 142458—
CatalystHCID 178465519HCID 178465519—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product3-(4-Phenyl-1-piperidinyl)pyridineHCID 1223802230%
Product4-(4-Phenylpiperidin-1-yl)pyridineHCID 1398883370%

Reaction Conditions

Temperature60 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-531a3861d3e44d8f886a5f66445818c7
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions