1H-1,2,4-Triazole → HCID 11785499, compound

Participants

Role	Name	HCID	Charge
Reactant	1H-1,2,4-Triazole	HCID 9257	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	HCID 11785717	HCID 11785717	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Solvent	Diethyl Ether	HCID 3283	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	HCID 11785499	HCID 11785499	—

Reaction Conditions

Temperature	195 °C

Reaction Steps

To a solution of 22.5 mg (0.043 mmol) of 3-(1(S)-(4-chlorobenzyl)-2(S)-((1-(4-bromophenyl)-2-cyano-2-methylpropyl)amino)propyl)benzonitrile in 0.5 mL of N-methyl-pyrrolidone, 12 mg (0.173 mmol) of 1,2,4-triazole, 2.3 mg of CuI and 24 mg of K2CO3 were added. The mixture was heated in a microwave reactor at 195° C. for 4 hr. The reaction was diluted with ether, washed with water, brine, dried and concentrated. The residue was purified by prep TLC using 50% EtOAc-hexane to isolate the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07390835B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-08a0ee66a0154e12ad6b0e63f9a9221c
Source note	uspto-grants-2008_06