反应详情

To a stirred solution of 0.61 g (2.04 mmol) N-(3-Benzoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-acetamide in 20 ml chloroform was added 1.2 g palladium on charcoal (10%). The mixture was stirred at room temperature for 15 minutes and then the solvent was removed in vacuo. The resulting powder was heated at 100° C. for 48 h and then suspended in ethyl acetate and dichloromethane. The suspension was filtered, and the organic phase was concentrated in vacuo to afford 0.26 g (44%) N-(3-benzoyl-benzo[b]thiophen-2-yl)-acetamide as a yellow solid. ES-MS m/e (%): 296 (M+H+, 100).

1. customthe solvent was removed in vacuo
2. temperatureThe resulting powder was heated at 100° C. for 48 h
3. filtrationThe suspension was filtered
4. concentrationthe organic phase was concentrated in vacuo